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Home > Safety Information > Guidance for treating physicians

Guidance for treating physicians

Reports from clinicians of events that have occurred during marketed use so far suggest that these events can occur as early as the first or second injection of Beovu, with patients reporting changes in vision, such as significant increase in floaters or blurry vision, within one to two weeks of treatment.

Before injecting, physicians are encouraged to look for signs of intraocular inflammation (IOI), which may include examination by slit lamp or posterior segment imaging. If active IOI is present, you must not perform an intraocular injection with Beovu and should treat the intraocular IOI according to medical practice. Please instruct your patients to contact you immediately if they notice any changes in visual acuity or any signs of inflammation, such as eye pain, floaters, discomfort or ocular hyperemia.

As a reminder, Beovu is contraindicated in patients with ocular or periocular infections, active intraocular IOI or known hypersensitivity to brolucizumab or any of the excipients. 

The clinical benefits and risks of brolucizumab apply to each treated eye and each injection. When treating bilaterally, physicians are reminded that adverse drug reactions can occur in each eye.

Physicians, other healthcare providers and patients are encouraged to report any observed or suspected adverse events according to local country requirements. You can make a report to Novartis at

Prescribing information and label updates

Label updates have been approved by several health authorities, including the FDA and the EMA to include characterization of the adverse events, retinal vasculitis (RV) and retinal vascular occlusion (RO), as part of the spectrum of IOI. RV and/or RO have been reported with the use of Beovu. These events have typically occurred in the presence of IOI.

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